The Impact of Neocidol on Hematological Parameters in Swiss Albino Mice
1 Department of Zoology, Faculty of Science, University of Benghazi, Libya.
2 Department of Molecular Diagnostic, Faculty of Biomedical Sciences, University of Benghazi, Libya.
3 Department of Histology, Faculty of Medicine, University of Benghazi, Benghazi, Libya.
Research Article
Open Access Research Journal of Life Sciences, 2024, 07(01), 038–045.
Article DOI: 10.53022/oarjls.2024.7.1.0024
Publication history:
Received on 27 January 2024; revised on 06 March 2024; accepted on 09 March 2024
Abstract:
Neocidol, containing Diazinon, stands as a prevalent compound in the fields of plant protection and insect control for public health. Despite its historical prominence, Neocidol, classified as a non-systemic organophosphate, exerts its effects by inhibiting cholinesterase, a pivotal enzyme in nerve transmission. In light of the widespread use of Neocidol in Libya and the absence of local studies, this research endeavors to assess its impact on blood parameters and the biochemistry of female white mice. The study involves prolonged tests wherein a sublethal concentration of 15 µl Neocidol per kg of body weight is introduced through the mice's drinking water. Toxicity assessments reveal noteworthy distinctions in various blood parameters between treated and untreated mice. Treated mice exhibit elevated leukocyte and erythrocyte values, coupled with diminished MCHC and MCV values. While blood chemistry results generally align between the control and treatment groups, an exception is observed in the form of heightened Alk-phosphatase values in treated mice. In summary, despite Neocidol's historical favorability in agricultural and public health pest control, this study underscores emerging criticisms concerning its identified health and environmental implications.
Keywords:
Neocidol, Diazinon; Blood parameters; Blood chemistry; Organophosphorus pesticides; Acetylcholinesterase
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